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Shadow of the Colossus: Official International site
The protagonist of the game is Wander, a young man whose goal is to resurrect a girl named "Mono". Little is known about Mono other than that she was sacrificed by her people because she was believed to have a cursed destiny. Assisting Wander in his quest to revive her is his loyal horse, Agro, who serves as his only ally in defeating the colossi.
Shadow of the Colossus (Spoiler warning!) @ Wikipedia